A multi-disciplinary designer, Oxman founded The Mediated Matter Group at the Massachusetts Institute of Technology in 2010 where she established and pioneered the field of Material Ecology, fusing technology and biology to deliver designs that align with principles of ecological sustainability. Oxman became a tenured professor at MIT in 2017.

Oxman received her PhD in Design Computation at MIT in 2010. Prior to that, she earned a diploma from the Architectural Association in London, complementing studies at the Faculty of Architecture and Town Planning at the Technion Israel Institute of Technology, and training at the Department of Medical Sciences at the Hebrew University, Jerusalem. Oxman was an architect and research consultant at Kohn Pedersen Fox Associates in London from 2004-05, during which she also served as Visiting Associate and Evaluator for SmartGeometry Group.